What is agmatine

Most human-based testing has utilized 2. Many supplements that contain agmatine sulfate will be focused on pre-workout or inducing pump, so the usual intake recommendation is around grams a day. Certain common ingredients in dietary supplements, herbs, and foods have been found to counteract or negate the effects of agmatine. These include arginine, citrulline, yohimbine, and D-aspartic acid.

Agmatine, on the other hand, decreases nNOS, and so the two do not play nice. By reducing the effectiveness of agmatine, arginine inhibits the neurological and physiological benefits you get from the chemical.

Citrulline and agmatine have similar interactions. Citrulline inhibits nNOS. For the best results when supplementing agmatine, you should also avoid taking it alongside protein. Any protein will decelerate the absorption of agmatine. To be safe, you should probably avoid supplementing with agmatine on the days you drink alcohol and vice versa.

Agmatine should never be mixed with alcohol because an increased risk of stomach ulcers has been reported through research. Agmatine is becoming more and more popular these days, mainly because the preliminary research shows promising results.

Hopefully, in the future, scientific research will provide us with more answers pertaining to just how useful agmatine supplementation truly is. Until then, despite speculation, there is nothing stopping you from giving this supplement a try.

There is nothing wrong with experimenting with different supplements to see if they work for you, as long as they are considered safe and you follow dosing instructions. Just remember that potential results are not the same as proven results. Search Supps See more "Close Cart". Best Sellers See more "Close Cart". Shop by Goal See more "Close Cart". Shop by Type See more "Close Cart".

Inside Gaspari See more "Close Cart". What Is Agmatine? Unchecked levels of iNOS may cause inflammation. Too much nNOS inhibits neuronal growth and repair. Endothelial NOS eNOS — signals for distillation to increase blood flow, lowering blood pressure and exportation of cellular waste.

By why do you want to use a byproduct of an amino acid as a supplement? Research has also shown that agmatine can reduce stress-induced depression symptoms in rats. Treatment also improved cognitive function in these rats, counteracting the dysfunction caused by stress-induced depression. Early human trials are beginning to verify that agmatine may be able to reduce symptoms of depression in humans.

One notable study examined the effects of supplementing 2 to 3 grams of agmatine daily in three subjects with major depressive disorder. During the trial, all three subjects showed complete remission of depressive symptoms. Interestingly, these antidepressant effects persisted even after simultaneously taking increasing daily doses of fenclonine during the trial.

These findings suggest that agmatine may be effective in reducing symptoms of depression independent of serotonin levels. In animal studies, agmatine has been shown to be effective against several types of anxiety. For example, one rat study found that agmatine significantly reduced alcohol withdrawal anxiety. In fact, anxiety is a common characteristic of hangovers. Even more, agmatine has shown potential to be effective against stress-induced anxiety.

One notable study examined the effects of agmatine on mice that had undergone 4 weeks of standardized stressors. In several different tests, agmatine supplementation was shown to significantly reduce anxiety-related behaviors.

For example, one study found that agmatine significantly reduced symptoms of anxiety in rats a mere 30 minutes after consumption. This suggests that agmatine may be effective against both chronic and acute anxiety. Research has shown that agmatine supplementation may protect brain cells from damage. Another benefit of agmatine is that it may help lower high blood pressure. It can help the body maintain normal, healthy blood pressure levels.

There are several advantages to this. Normal blood pressure means improved overall health. It also means better nutrient delivery. These two factors contribute to a better muscle-building environment. When it comes to agmatine sulfate benefits, most people think in terms of better pumps. Yet, agmatine has more cognitive benefits than many people may realize. Furthermore, it is believed that agmatine sulfate has neuroprotective benefits. One of the agmatine sulfate benefits is protection against brain damage caused by a stroke.

This is because increased eNOS dilates blood vessels. In turn, this improves blood flow to the brain. Another effect of a stroke is a lack of oxygen. Less blood flow means reduced oxygen to the brain. Agmatine sulfate works synergistically with every other pump enhancer in these two powerful formulas.

The combination creates the most powerful pre-workout stack you can buy. What Is Agmatine Sulfate? This means increased blood flow. Of course, that means it promotes the pump. It also delivers oxygen and nutrients to muscles while removing cellular waste products. Agmatine Can Help Build Muscle Agmatine releases the luteinizing hormone LH which in turn, can increase testosterone levels in the body. Agmatine Sulfate References: Reis, D.

Is agmatine a novel neurotransmitter in the brain?. Trends in pharmacological sciences, 21 5 , — Agmatine, a novel hypothalamic amine, stimulates pituitary luteinizing hormone release in vivo and hypothalamic luteinizing hormone-releasing hormone release in vitro. Neuroscience Letters, 3 , — Is agmatine an endogenous factor against stress? Abstract There is presently a great interest in the therapeutic potential of agmatine, decarboxylated arginine, for various diseases. Publication types Case Reports.

Substances Agmatine.